About the disease

Diffuse intrinsic pontine glioma is one of the most aggressive and deadliest forms of childhood cancer.

It is a rare disease with an annual incidence of 1-2 new cases / 100,000 population. The median survival of children with this disease is less than 1 year after diagnosis and there has been no improvement in prognosis for more than 30 years now.

Surgical treatment is generally not recommended due to the diffuse presence of the tumor within the delicate structure of the brainstem, which houses almost all vital function centers and pathways.

Despite extensive research efforts, currently available chemotherapeutics have not brought significant improvement in terms of survival. At the moment the most common treatment is radiation, which offers only temporary relief.

Prospects for improvement

The results of recent research have contributed to the understanding of the molecular mechanisms involved in the development of this devastating form of cancer, bringing new hope for future success in identifying effective treatments.

Promising preclinical studies investigating epigenetic modifiers and other forms of molecularly targeted therapy hold significant potential to advance treatment and have progressed to subsequent phases of clinical research.

In addition, immunotherapy, specifically CAR T-cell therapy, oncolytic viruses, and vaccine therapy are other promising approaches for the effective treatment of this disease.

Our goal is to promote new options for glioma treatment and patient care in Czech Republic and to improve the situation of pediatric patients whose only current option is treatment abroad.

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Support Us

You can send your financial contribution by wire transfer to the Foundation's transparent account 2802771017 / 2010. Alternatively, you can contribute via QR code.

Main objectives of the Foundation

  • To support the expansion of knowledge and initiatives, and ultimately contribute to advancements in oncology, neurosurgery, and the treatment of gliomas in the Czech Republic and worldwide
  • Development and improvement of diagnostic and therapeutic methods in oncology and particularly  in glioma treatment
  • To support the introduction of advanced medical methods to oncology and glioma treatment
  • To support the education and training of oncological experts and neurosurgeons by organizing and supporting their participation in scientific conferences, symposia, courses, workshops, training sessions, and scientific internships
  • To support the development and modernization of specialized oncology and neurosurgery departments in the Czech Republic
  • To support publishing and research activities in oncology, especially in the field of brain tumors
  • To provide grants for the acquisition, extension, and improvement of instruments, equipment, and medical consumables for oncology and neurosurgery departments in the Czech Republic
  • To provide grants for the treatment of cancer patients in the Czech Republic and abroad, especially children, including the associated costs of accommodation, meals, travel expenses, etc
  • To support the families of cancer patients, especially children. Specifically, to provide grants to cover the treatment and treatment related costs in the Czech Republic and abroad, including the costs and expenses of the families of cancer patients (e.g. accommodation, travel costs, and compensation for the loss of earnings for family members caring for cancer patients)
  • Support for hospice care at home and support for palliative care for cancer patients

Subject Matter Expert

Doc. MUDr. Martin Chovanec, Ph.D., MHA

Specializing in skull base surgery, otology, head and neck oncology, reconstructive surgery, salivary gland surgery, thyroid surgery, facial nerve palsy resuscitation surgery, clinical head and neck anatomy, and cell/tumor biology.

Head of the Department of Otorhinolaryngology at the 3rd Faculty of Medicine, Charles University in Prague and the Faculty of Medicine, Královské Vinohrady since 2015. Prior to this, he worked at Department of Otorhinolaryngology, 1st Faculty of Medicine, Charles University in Prague and the Faculty of Medicine, Motol.

A member of professional associations, serving on the accreditation committee of the Ministry of Health of the Czech Republic for specialisation training in Otorhinolaryngology, Head and Neck Surgery, and Paediatric Otorhinolaryngology.

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